The Anti-Covid-19 Spike mAb IgG(05FC) Antibody from Bioassay Technology Laboratory is a Human Monoclonal antibody. This antibody recognizes 2019-nCoV, Corona Virus, Coronavirus, COVID-19, SARS-CoV-2, and Virus antigen. The Anti-Covid-19 Spike mAb IgG(05FC) Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Coronaviruses (CoVs) infect human and animals and cause varieties of diseases, including respiratory, enteric, renal, and neurological diseases. CoV uses its spike protein to recognize ACE2 as its receptors and mediate membrane fusion and virus entry into host cells(PMID: 32221306). Each monomer of trimeric S protein is about 180 kDa, and contains two subunits, S1 and S2,S1 recognizes and binds to host receptors, and subsequent conformational changes in S2 facilitate fusion between the viral envelope and the host cell membrane(PMID: 19198616). Although the amino acid sequences of the S-glycoprotein were found to be different between the various HCoV, the structures showed high similarity, but the best 3D structural overlap shared by SARS-CoV and SARS-CoV-2, consistent with the shared ACE2 predicted receptor (PMID: 32522207). The spike protein of CoVs can be a target for vaccine and therapeutic development (PMID: 19198616)